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rsbR [2017-8-11 16:0:3]
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rsbR [2017-8-11 16:0:3]

Locus
BSU04670
Isoelectric point
4.73
Molecular weight
30.90 kDa
Protein length
274 aa Sequence Blast
Gene length
822 bp Sequence Blast
Function
control of SigB activity
Product
activator of RsbT kinase activity, stressosome sensor protein
Essential
no
Synonyms
ycxR,rsbRA

Genomic Context

      
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Categories containing this gene/protein

Gene

Coordinates
519,408 → 520,232

The protein

Catalyzed reaction/ biological activity

  • positive regulator of YtvA-dependent light activation of the SigB stress response PubMed
  • phosphorylated RsbR activates the kinase activity of RsbT PubMed
  • Paralogous protein(s)

    Domains

  • RsbRA is composed of an N-terminal nonheme globin domain and a highly conserved C-terminal STAS (Sulphate Transporter and AntiSigma factor antagonist) domain. The C-terminal STAS domain is the target of the serine/threonine-specific kinase RsbT (see below).
  • Modification

  • phosphorylation on Thr-171 and Thr-205 by RsbT PubMed
  • Structure

  • 2BNL (N-terminal domain), 3VY9 (complete stressosome)
  • Additional information

  • belongs to the 100 most abundant proteins PubMed
  • Expression and Regulation

    Operons

    Description

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon
  • SigB: sigma factor, PubMed, in SigB regulon
  • Regulatory mechanism

  • CcpA: repression, PubMed, in CcpA regulon
  • Regulation

  • rsbV: induced by stress (SigB) PubMed
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    Labs working on this gene/protein

  • Bill Haldenwang, San Antonio, USA
  • Chet Price, Davis, USA homepage
  • Rick Lewis, Newcastle, UK homepage
  • References

    Reviews

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    Original Articles

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